# Tacrolimus (Tacrolimus)

Source: https://ourhealthnetwork.com/drugs/tacrolimus
Data: FDA Orange Book and OpenFDA, refreshed periodically

## What is Tacrolimus?

Tacrolimus is an immunosupressant. It is prescribed to treat graft vs host disease, dermatitis, atopic. Across the United States, 11,000 doctors prescribe Tacrolimus to approximately 115,000 Medicare patients.

## Brand names

Tacrolimus

## Indications

Tacrolimus is prescribed for the treatment of graft vs host disease, dermatitis and atopic.

## Conditions treated

- [Graft vs Host Disease](https://ourhealthnetwork.com/conditions/graft-vs-host-disease)
- [Dermatitis](https://ourhealthnetwork.com/conditions/dermatitis)
- [Atopic](https://ourhealthnetwork.com/conditions/atopic)

## Mechanism of action

Tacrolimus binds to an intracellular protein, FKBP-12. A complex of tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin (a ubiquitous mammalian intracellular enzyme) is then formed and the phosphatase activity of calcineurin is inhibited.

## Drug classification

- Established Pharmacologic Class: immunosupressants
- Route of administration: ORAL

## Common side effects

constipation, diarrhea, nausea, peripheral edema, tremor and anemia

## Sources and disclaimers

- FDA Orange Book and OpenFDA dataset
- This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional before starting, stopping, or changing any medication.

## Related

- [All drugs](https://ourhealthnetwork.com/drugs)
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- [Methodology](https://ourhealthnetwork.com/methodology)