# Migalastat Hcl (Galafold)

Source: https://ourhealthnetwork.com/drugs/migalastat-hcl
Data: FDA Orange Book and OpenFDA, refreshed periodically

## What is Migalastat Hcl?

Migalastat Hcl (brand name: Galafold) is an alpha-galactosidase a (alpha-gal a) pharmacological chaperone. It is prescribed to treat fabry disease.

## Brand names

Galafold

## Indications

Migalastat Hcl is primarily prescribed for the treatment of fabry disease.

## Conditions treated

- [Fabry Disease](https://ourhealthnetwork.com/conditions/fabry-disease)

## Mechanism of action

Migalastat is a pharmacological chaperone that reversibly binds to the active site of the alpha-galactosidase A (alpha-Gal A) protein (encoded by the galactosidase alpha gene, GLA ), which is deficient in Fabry disease. This binding stabilizes alpha-Gal A allowing its trafficking from the endoplasmic reticulum into the lysosome where it exerts its action.

## Drug classification

- Established Pharmacologic Class: alpha-galactosidase A (alpha-Gal A) pharmacological chaperones
- Route of administration: ORAL

## Common side effects

double-blind phase of study 1 were headache, nasopharyngitis, nausea, pyrexia, urinary tract infection

## Sources and disclaimers

- FDA Orange Book and OpenFDA dataset
- This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional before starting, stopping, or changing any medication.

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