# Lofexidine Hcl (Lofexidine Hydrochloride)

Source: https://ourhealthnetwork.com/drugs/lofexidine-hcl
Data: FDA Orange Book and OpenFDA, refreshed periodically

## What is Lofexidine Hcl?

Lofexidine Hcl (brand name: Lofexidine Hydrochloride) is a central alpha adrenergic agonist. It is prescribed to treat substance withdrawal syndrome. Across the United States, 11 doctors prescribe Lofexidine to approximately 245 Medicare patients.

## Brand names

Lofexidine Hydrochloride

## Indications

Lofexidine Hcl is primarily prescribed for the treatment of substance withdrawal syndrome.

## Conditions treated

- [Substance Withdrawal Syndrome](https://ourhealthnetwork.com/conditions/substance-withdrawal-syndrome)

## Mechanism of action

Lofexidine is a central alpha-2 adrenergic agonist that binds to receptors on adrenergic neurons. This reduces the release of norepinephrine and decreases sympathetic tone.

## Drug classification

- Established Pharmacologic Class: central alpha adrenergic agonists
- Route of administration: ORAL

## Common side effects

bradycardia, dizziness, dry mouth, hypotension, orthostatic hypotension, sedation, somnolence

## Sources and disclaimers

- FDA Orange Book and OpenFDA dataset
- This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional before starting, stopping, or changing any medication.

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