# Duloxetine Hcl (Cymbalta)

Source: https://ourhealthnetwork.com/drugs/duloxetine-hcl
Data: FDA Orange Book and OpenFDA, refreshed periodically

## What is Duloxetine Hcl?

Duloxetine Hcl (brand name: Cymbalta) is a serotonin-norepinephrine reuptake inhibitor (snri). It is prescribed to treat major depressive disorder, anxiety disorders, diabetic neuropathies. Across the United States, 220,000 doctors prescribe Duloxetine to approximately 2.1 million Medicare patients, making it one of the 50 most prescribed drugs in America.

## Brand names

Cymbalta

## Indications

Duloxetine Hcl is prescribed for several conditions including major depressive disorder, anxiety disorders, diabetic neuropathies, among others.

## Conditions treated

- [Major Depressive Disorder](https://ourhealthnetwork.com/conditions/major-depressive-disorder)
- [Anxiety Disorders](https://ourhealthnetwork.com/conditions/anxiety-disorders)
- [Diabetic Neuropathies](https://ourhealthnetwork.com/conditions/diabetic-neuropathies)
- [Musculoskeletal Pain](https://ourhealthnetwork.com/conditions/musculoskeletal-pain)

## Mechanism of action

Although the exact mechanisms of the antidepressant, central pain inhibitory and anxiolytic actions of duloxetine in humans are unknown, these actions are believed to be related to its potentiation of serotonergic and noradrenergic activity in the CNS.

## Drug classification

- Established Pharmacologic Class: Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)
- Route of administration: ORAL

## Common side effects

nausea, dry mouth, constipation, fatigue, decreased appetite, drowsiness

## Sources and disclaimers

- FDA Orange Book and OpenFDA dataset
- This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional before starting, stopping, or changing any medication.

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