# Colesevelam Hcl (Colesevelam Hydrochloride)

Source: https://ourhealthnetwork.com/drugs/colesevelam-hcl
Data: FDA Orange Book and OpenFDA, refreshed periodically

## What is Colesevelam Hcl?

Colesevelam Hcl (brand name: Colesevelam Hydrochloride) is a bile acid sequestrant. It is prescribed to treat enterocolitis, pseudomembranous, diarrhea. Across the United States, 6,000 doctors prescribe Colesevelam to approximately 8,000 Medicare patients.

## Brand names

Colesevelam Hydrochloride

## Indications

Colesevelam Hcl is prescribed for several conditions including enterocolitis, pseudomembranous, diarrhea, among others.

## Conditions treated

- [Enterocolitis](https://ourhealthnetwork.com/conditions/enterocolitis)
- [Pseudomembranous](https://ourhealthnetwork.com/conditions/pseudomembranous)
- [Diarrhea](https://ourhealthnetwork.com/conditions/diarrhea)
- [Diabetes Mellitus](https://ourhealthnetwork.com/conditions/diabetes-mellitus)
- [Type 2](https://ourhealthnetwork.com/conditions/type-2)
- [Hypertriglyceridemia](https://ourhealthnetwork.com/conditions/hypertriglyceridemia)
- [Hyperlipoproteinemias](https://ourhealthnetwork.com/conditions/hyperlipoproteinemias)
- [Coronary Artery Disease](https://ourhealthnetwork.com/conditions/coronary-artery-disease)
- [Hypercholesterolemia](https://ourhealthnetwork.com/conditions/hypercholesterolemia)

## Mechanism of action

Primary Hyperlipidemia : Colesevelam hydrochloride, the active pharmaceutical ingredient, is a non-absorbed, lipid-lowering polymer that binds bile acids in the intestine, impeding their reabsorption. As the bile acid pool becomes depleted, the hepatic enzyme, cholesterol 7-α-hydroxylase, is upregulated, which increases the conversion of cholesterol to bile acids.

## Drug classification

- Established Pharmacologic Class: bile acid sequestrants
- Route of administration: ORAL

## Common side effects

and nausea, blind period and included headache, influenza, nasopharyngitis, upper respiratory tract infection

## Sources and disclaimers

- FDA Orange Book and OpenFDA dataset
- This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional before starting, stopping, or changing any medication.

## Related

- [All drugs](https://ourhealthnetwork.com/drugs)
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- [Methodology](https://ourhealthnetwork.com/methodology)